TRIAL INNOVATION NETWORK AT UCLA CTSI
The CTSI TIN Liaison Team offers consultations and can help connect you with TIN resources.
Please email GSU@mednet.ucla.edu to schedule an appointment.
TIN Events
The Trial Innovation Network (TIN) provides support to investigators conducting or looking to initiate multi-site clinical trials and studies. By working with the UCLA CTSI TIN Liaison, CTSI’s partner sites (including UCLA, Cedars-Sinai, Charles R. Drew University, and Lundquist/Harbor-UCLA) can gain the additional support they need to successfully conduct multi-site studies. The TIN Liaison at UCLA can help you connect with local experts, obtain TIN services, and facilitate individual consultations with TIN experts.
Services can include support or access to:- Standard agreements
- Single IRB support
- Recruitment and retention plans
- Recruitment and feasibility assessments
- Patient recruitment materials
- Community engagement studios
- EHR-based cohort assessment
- Efficacy-to-Effectiveness Trial Design
- Data and Safety Monitoring
- NEW: TIN Toolbox
- Study design
- Study budget development
- Project timelines
- Recruitment
- Study feasibility
TIN is a collaborative initiative within the CTSA Program that aims to address critical roadblocks in clinical research and accelerate translational science. TIN's collaborative national network focuses on operational innovation, operational excellence, and collaboration and leverages the expertise and resources of the CTSA Program. The TIN features a single IRB system, master contracting agreements, quality by design approaches, and a focus on evidence-based strategies for patient recruitment and engagement.
The goal of the TIN is to not only execute trials better, faster, and more cost-efficiently but, importantly, to be a national laboratory to study, understand and innovate the process of conducting clinical trials.
The CTSA Program Hubs, including the UCLA CTSI, and other clinical research institutions are the frontline of the TIN. The UCLA CTSI TIN Liaison Team uses their experience and knowledge of the local environment to facilitate collaboration with the TIN in developing and disseminating clinical trial innovations and excellence.
Contact the TIN Liaison today to get access to TIN resources, obtain individual consultations, or find out what the UCLA CTSI has to offer for supporting your multi-site clinical study.
| PRIMARY CONTACT Jordan Daniel UCLA CTSI TIN Liaison / Point-of-contact 310-206-0069 jordandaniel@mednet.ucla.edu |
GENERAL MAILBOX TIN@mednet.ucla.edu |
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UCLA CTSI TIN LEADERSHIP
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MEDICAL DIRECTOR Arash Naeim
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UCLA CTSI TIN LIAISON TEAM Terra Hughes |
Alice Young-Singleton Anne Skinner
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The complexity of contract negotiations can be a major barrier to timely study start-up. With this service, TIN provides recommendations on how to use the FDP-CTSA agreement. This Standard Agreement can potentially be used by each of the participating institutions in your multi-site study, especially if you submit your proposal prior to contract initiation.
Recent policy changes by the NIH and DHHS require the use of a single IRB of record for multi-site research to reduce redundant IRB review and to streamline investigator submission processes. TIN has established three Central IRBs (CIRBs), which are based on the SMART IRB Authorization Agreement. TIN can provide support, resources, tools, and a web-based platform (IREx) to ensure all site investigators understand how to use a sIRB at their institution, from initial submission to study closeout.
Working with your local UCLA CTSI TIN Liaison, TIN can provide you:
- Support, resources, and tools, for creating a Single IRB Plan
- A web-based platform (IREx) to track site progress towards initial approval, documenting reliance arrangements, capturing study-specific local considerations and storing, disseminating sites’ IRB approvals; and facilitating communications
- Introductory training ensuring all site investigators understand how to use a sIRB at their institution
- Support developing a study team communication plan
- Informed consent form templates
Contact the UCLA CTSI TIN Liaison today to get started.
Recruitment and Retention Planning
Key features include:
- Comprehensive review of your study and existing recruitment plan
- Identification of stakeholders and recruitment partners (such as providers and community organizations) as well as recruitment locations
- Guidance on understanding unique needs and preferences of potential participants as well as barriers and facilitators to recruitment and retention
- Tailored recommendations for engaging participants from your study population
Recruitment Feasibility Assessment
Key features include:
- Comprehensive review of your study and budget
- Assessment of the likelihood your study will meet predefined recruitment and retention goals
- Tailored advice on how to enhance feasibility
Recruitment Materials
Key features include:
- Review of materials needs, including dissemination plans
- Recommendations and templates that might improve the recruitment of potential participants for specific studies
These consultative studios allow for divers groups of stakeholders to be involved in the planning and implementation of research. Studios can facilitate guidance on identifying and addressing barriers to participation and how to develop or refine recruitment materials and messages.
Key features of this TIN service may include:
- Assessing whether a studio might be appropriate based on the needs of a study and if so, where a studio has the potential to be most valuable
- Advice on when and how to conduct studios
TIN helps investigators consider ways that Electronic Health Record (EHR) data may be leveraged to inform study design and potential site selection. Services include expert clinical and technical review of a study’s goal recruitment population and high level assessment of computable phenotyping. Funded projects may also request and receive support required to organize distribution of phenotype algorithms to potential CTSA hubs and collation of results.
Initial Consultations
E2E Consultations: Efficacy to Effectiveness Trial Design
E2E consultations may include:
- Working with an investigator to design a study that includes both efficacy and effectiveness endpoints
- Providing advice on suitable populations to include in the effectiveness phase of the trial
- Creating a statistical analysis plan
- Identifying the role of the Data Safety Monitoring Board in moving from the efficacy to the effectiveness phase
For additional events beyond those highlighted above in "TIN Events," TIN offers a number of Network Events open to the general public.
Collaboration Webinars: Hear from CTSA Program experts on various trial-related topics to improve your project.
Open Forums: Hear from Network Project Leads on various Network topics and have an opportunity to ask questions and receive information. These standing sessions will be held once a month and will generally be 60 minutes in length. The forums will be informal with introductory slides leading into an open dialogue session.
