Vera Chesnokova • UCLA Profiles

Vera M Chesnokova

Title(s)	Adjunct Professor, Medicine
School	Medicine
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Research

Research Activities and Funding

Role of p21 in antidepressant-induced neurogenesis
NIH R21MH079988Dec 10, 2007 - Nov 30, 2010
Role: Principal Investigator

LIF MEDIATES ACTH AXIS RESPONSE TO INFLAMMATION
NIH R29DK054862Feb 10, 1999 - Jan 31, 2004
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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WIP1 is a novel specific target for growth hormone action. iScience. 2023 Nov 17; 26(11):108117. Apaydin T, Zonis S, Zhou C, Valencia CW, Barrett R, Strous GJ, Mol JA, Chesnokova V, Melmed S. PMID: 37876819; PMCID: PMC10590974.

View in: PubMed Mentions:
Non-pituitary GH regulation of the tissue microenvironment. Endocr Relat Cancer. 2023 07 01; 30(7). Chesnokova V, Melmed S. PMID: 37066857; PMCID: PMC10247477.

View in: PubMed Mentions: 1 Fields:
End Endocrinology Neo Neoplasms
Translation:Humans
The Multiple Faces of the GH/IGF Axis. Cells. 2022 01 10; 11(2). Chesnokova V. PMID: 35053333; PMCID: PMC8773948.

View in: PubMed Mentions: Fields:
Bio Biophysics Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Cell Rep. 2021 12 14; 37(11):110068. Chesnokova V, Zonis S, Apostolou A, Estrada HQ, Knott S, Wawrowsky K, Michelsen K, Ben-Shlomo A, Barrett R, Gorbunova V, Karalis K, Melmed S. PMID: 34910915; PMCID: PMC8716125.

View in: PubMed Mentions: 8 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
GH and Senescence: A New Understanding of Adult GH Action. J Endocr Soc. 2022 Jan 01; 6(1):bvab177. Chesnokova V, Melmed S. PMID: 34909519; PMCID: PMC8664681.

View in: PubMed Mentions: 3
DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas. J Clin Invest. 2020 11 02; 130(11):5738-5755. Ben-Shlomo A, Deng N, Ding E, Yamamoto M, Mamelak A, Chesnokova V, Labadzhyan A, Melmed S. PMID: 32673291; PMCID: PMC7598090.

View in: PubMed Mentions: 24 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
Peptide Hormone Regulation of DNA Damage Responses. Endocr Rev. 2020 07 01; 41(4). Chesnokova V, Melmed S. PMID: 32270196; PMCID: PMC7279704.

View in: PubMed Mentions: 6 Fields:
End Endocrinology
Translation:Humans Animals Cells
Growth hormone in the tumor microenvironment. Arch Endocrinol Metab. 2019 Nov-Dec; 63(6):568-575. Chesnokova V, Melmed S. PMID: 31939481; PMCID: PMC7025769.

View in: PubMed Mentions: 17 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Growth Hormone Induces Colon DNA Damage Independent of IGF-1. Endocrinology. 2019 06 01; 160(6):1439-1447. Chesnokova V, Zonis S, Barrett RJ, Gleeson JP, Melmed S. PMID: 31002310; PMCID: PMC6530523.

View in: PubMed Mentions: 16 Fields:
End Endocrinology
Translation:Humans Animals Cells
Excess growth hormone suppresses DNA damage repair in epithelial cells. JCI Insight. 2019 Feb 07; 4(3). Chesnokova V, Zonis S, Barrett R, Kameda H, Wawrowsky K, Ben-Shlomo A, Yamamoto M, Gleeson J, Bresee C, Gorbunova V, Melmed S. PMID: 30728323; PMCID: PMC6413789.

View in: PubMed Mentions: 21 Fields:
Med Medicine (General)
Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. J Neuroinflammation. 2018 Sep 11; 15(1):260. Zonis S, Breunig JJ, Mamelak A, Wawrowsky K, Bresee C, Ginzburg N, Chesnokova V. PMID: 30201019; PMCID: PMC6131894.

View in: PubMed Mentions: 4 Fields:
Neu Neurology
Translation:Humans Animals Cells
Androgen Receptor Regulation of Local Growth Hormone in Prostate Cancer Cells. Endocrinology. 2017 07 01; 158(7):2255-2268. Recouvreux MV, Wu JB, Gao AC, Zonis S, Chesnokova V, Bhowmick N, Chung LW, Melmed S. PMID: 28444169; PMCID: PMC5505214.

View in: PubMed Mentions: 13 Fields:
End Endocrinology
Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):E3250-9. Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S. PMID: 27226307; PMCID: PMC4988562.

View in: PubMed Mentions: 48 Fields:
Sci Science
Translation:Humans Animals Cells
Chronic peripheral inflammation, hippocampal neurogenesis, and behavior. Brain Behav Immun. 2016 Nov; 58:1-8. Chesnokova V, Pechnick RN, Wawrowsky K. PMID: 26802985; PMCID: PMC4956598.

View in: PubMed Mentions: 96 Fields:
All Allergy and Immunology Bra Brain Psy Psychophysiology
Translation:Humans Animals
New Signaling Pathway for Gut-Brain Interactions. Neuropsychopharmacology. 2016 Jan; 41(1):372-3. Chesnokova V, Pechnick RN. PMID: 26657951; PMCID: PMC4677132.

View in: PubMed Mentions: 1 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Humans Animals Cells
Chronic intestinal inflammation alters hippocampal neurogenesis. J Neuroinflammation. 2015 Apr 03; 12:65. Zonis S, Pechnick RN, Ljubimov VA, Mahgerefteh M, Wawrowsky K, Michelsen KS, Chesnokova V. PMID: 25889852; PMCID: PMC4403851.

View in: PubMed Mentions: 67 Fields:
Neu Neurology
Translation:Animals Cells
p21Cip restrains hippocampal neurogenesis and protects neuronal progenitors from apoptosis during acute systemic inflammation. Hippocampus. 2013 Dec; 23(12):1383-94. Zonis S, Ljubimov VA, Mahgerefteh M, Pechnick RN, Wawrowsky K, Chesnokova V. PMID: 23966332; PMCID: PMC4170945.

View in: PubMed Mentions: 28 Fields:
Bra Brain
Translation:Animals Cells
Growth hormone is a cellular senescence target in pituitary and nonpituitary cells. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3331-9. Chesnokova V, Zhou C, Ben-Shlomo A, Zonis S, Tani Y, Ren SG, Melmed S. PMID: 23940366; PMCID: PMC3761588.

View in: PubMed Mentions: 37 Fields:
Sci Science
Translation:Humans Animals Cells
Constitutive somatostatin receptor subtype 2 activity attenuates GH synthesis. Endocrinology. 2013 Jul; 154(7):2399-409. Ben-Shlomo A, Pichurin O, Khalafi R, Zhou C, Chesnokova V, Ren SG, Liu NA, Melmed S. PMID: 23696564; PMCID: PMC3689284.

View in: PubMed Mentions: 7 Fields:
End Endocrinology
Translation:Humans Animals Cells
Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth. Mol Endocrinol. 2012 Dec; 26(12):2092-103. Chesnokova V, Zonis S, Wawrowsky K, Tani Y, Ben-Shlomo A, Ljubimov V, Mamelak A, Bannykh S, Melmed S. PMID: 23051594; PMCID: PMC3517712.

View in: PubMed Mentions: 13 Fields:
End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Estradiol partially recapitulates murine pituitary cell cycle response to pregnancy. Endocrinology. 2012 Oct; 153(10):5011-22. Toledano Y, Zonis S, Ren SG, Wawrowsky K, Chesnokova V, Melmed S. PMID: 22851678; PMCID: PMC3512024.

View in: PubMed Mentions: 1 Fields:
End Endocrinology
Translation:Animals
Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampus. PLoS One. 2011; 6(11):e27290. Pechnick RN, Zonis S, Wawrowsky K, Cosgayon R, Farrokhi C, Lacayo L, Chesnokova V. PMID: 22076148; PMCID: PMC3208633.

View in: PubMed Mentions: 32 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Lineage-specific restraint of pituitary gonadotroph cell adenoma growth. PLoS One. 2011 Mar 25; 6(3):e17924. Chesnokova V, Zonis S, Zhou C, Ben-Shlomo A, Wawrowsky K, Toledano Y, Tong Y, Kovacs K, Scheithauer B, Melmed S. PMID: 21464964; PMCID: PMC3064664.

View in: PubMed Mentions: 19 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Molecular mechanisms of pituitary adenoma senescence. Front Horm Res. 2010; 38:7-14. Chesnokova V, Zonis S, Ben-Shlomo A, Wawrowsky K, Melmed S. PMID: 20616490.

View in: PubMed Mentions: 6 Fields:
End Endocrinology
Translation:Humans Animals
Pituitary senescence: the evolving role of Pttg. Mol Cell Endocrinol. 2010 Sep 15; 326(1-2):55-9. Chesnokova V, Melmed S. PMID: 20153804; PMCID: PMC2906651.

View in: PubMed Mentions: 19 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Humans Animals
Differential Ligand-Mediated Pituitary Somatostatin Receptor Subtype Signaling: Implications for Corticotroph Tumor Therapy. Endocr Rev. 2009 Dec 01; 30(7):933. Ben-Shlomo A, Schmid H, Wawrowsky K, Pichurin O, Hubina E, Chesnokova V, Liu NA, Culler M, Melmed S. PMID: 28199544.

View in: PubMed Mentions: Fields:
End Endocrinology
Differential ligand-mediated pituitary somatostatin receptor subtype signaling: implications for corticotroph tumor therapy. J Clin Endocrinol Metab. 2009 Nov; 94(11):4342-50. Ben-Shlomo A, Schmid H, Wawrowsky K, Pichurin O, Hubina E, Chesnokova V, Liu NA, Culler M, Melmed S. PMID: 19820006.

View in: PubMed Mentions: 31 Fields:
End Endocrinology Met Metabolism
Translation:Humans Animals
Pituitary tumour-transforming gene (PTTG) and pituitary senescence. Horm Res. 2009 Apr; 71 Suppl 2:82-7. Chesnokova V, Melmed S. PMID: 19407503.

View in: PubMed Mentions: 8 Fields:
End Endocrinology
Translation:Humans Animals
Pituitary adenoma growth: a model for cellular senescence and cytokine action. Cell Cycle. 2009 Mar 01; 8(5):677-8. Arzt E, Chesnokova V, Stalla GK, Melmed S. PMID: 19223763; PMCID: PMC2710531.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology
Translation:Humans Cells
Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence. Endocrinology. 2009 Jun; 150(6):2603-10. Chesnokova V, Wong C, Zonis S, Gruszka A, Wawrowsky K, Ren SG, Benshlomo A, Yu R. PMID: 19213844; PMCID: PMC2689808.

View in: PubMed Mentions: 15 Fields:
End Endocrinology
Translation:Animals Cells
Constitutive somatostatin receptor activity determines tonic pituitary cell response. Mol Endocrinol. 2009 Mar; 23(3):337-48. Ben-Shlomo A, Zhou C, Pichurin O, Chesnokova V, Liu NA, Culler MD, Melmed S. PMID: 19131507; PMCID: PMC2725764.

View in: PubMed Mentions: 14 Fields:
End Endocrinology Mol Molecular Biology
Translation:Humans Cells
Adult neurogenesis, cell cycle and drug discovery in psychiatry. Neuropsychopharmacology. 2009 Jan; 34(1):244. Pechnick RN, Chesnokova V. PMID: 19079068; PMCID: PMC2878176.

View in: PubMed Mentions: 2 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Humans Animals
p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17498-503. Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S. PMID: 18981426; PMCID: PMC2577704.

View in: PubMed Mentions: 55 Fields:
Sci Science
Translation:Animals
lin-Sca-1+ cells and age-dependent changes of their proliferation potential are reliant on mesenchymal stromal cells and are leukemia inhibitory factor dependent. Gerontology. 2008; 54(5):312-23. Schraml E, Fehrer C, Brunauer R, Lepperdinger G, Chesnokova V, Schauenstein K. PMID: 18841027.

View in: PubMed Mentions: 3 Fields:
Ger Geriatrics
Translation:Animals Cells
Antidepressants and Cdk inhibitors: releasing the brake on neurogenesis? Cell Cycle. 2008 Aug; 7(15):2321-6. Chesnokova V, Pechnick RN. PMID: 18682686; PMCID: PMC2879159.

View in: PubMed Mentions: 9 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1358-63. Pechnick RN, Zonis S, Wawrowsky K, Pourmorady J, Chesnokova V. PMID: 18172194; PMCID: PMC2234143.

View in: PubMed Mentions: 55 Fields:
Sci Science
Translation:Animals Cells
Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res. 2007 Nov 01; 67(21):10564-72. Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S. PMID: 17975001; PMCID: PMC2770267.

View in: PubMed Mentions: 43 Fields:
Neo Neoplasms
Translation:Animals Cells
Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C1082-92. Rubinek T, Chesnokova V, Wolf I, Wawrowsky K, Vlotides G, Melmed S. PMID: 17626243.

View in: PubMed Mentions: 7 Fields:
Cel Cell Biology Phy Physiology
Translation:Animals Cells
Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive receptor activation. Mol Endocrinol. 2007 Oct; 21(10):2565-78. Ben-Shlomo A, Pichurin O, Barshop NJ, Wawrowsky KA, Taylor J, Culler MD, Chesnokova V, Liu NA, Melmed S. PMID: 17609435.

View in: PubMed Mentions: 17 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Developmental exposure to corticosterone: behavioral changes and differential effects on leukemia inhibitory factor (LIF) and corticotropin-releasing hormone (CRH) gene expression in the mouse. Psychopharmacology (Berl). 2006 Mar; 185(1):76-83. Pechnick RN, Kariagina A, Hartvig E, Bresee CJ, Poland RE, Chesnokova VM. PMID: 16416158.

View in: PubMed Mentions: 5 Fields:
Psy Psychopharmacology
Translation:Animals
Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis. FEBS Lett. 2005 Aug 15; 579(20):4465-9. Ware CB, Kariagina A, Zonis S, Alon D, Chesnokova V. PMID: 16081071.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Animals Cells
Leukemia inhibitory factor regulates glucocorticoid receptor expression in the hypothalamic-pituitary-adrenal axis. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E857-63. Kariagina A, Zonis S, Afkhami M, Romanenko D, Chesnokova V. PMID: 15985451.

View in: PubMed Mentions: 4 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis. Mol Endocrinol. 2005 Sep; 19(9):2371-9. Chesnokova V, Kovacs K, Castro AV, Zonis S, Melmed S. PMID: 15919720; PMCID: PMC1201444.

View in: PubMed Mentions: 52 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Reduced immobility in the forced swim test in mice with a targeted deletion of the leukemia inhibitory factor (LIF) gene. Neuropsychopharmacology. 2004 Apr; 29(4):770-6. Pechnick RN, Chesnokova VM, Kariagina A, Price S, Bresee CJ, Poland RE. PMID: 14970834.

View in: PubMed Mentions: 16 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Animals
Increased leptin and white adipose tissue hypoplasia are sexually dimorphic in Lif null/Igf-I haploinsufficient mice. FEBS Lett. 2004 Jan 16; 557(1-3):64-8. Fernández-Moreno C, Pichel JG, Chesnokova V, De Pablo F. PMID: 14741342.

View in: PubMed Mentions: 6 Fields:
Bio Biochemistry
Translation:Animals
Hypothalamic-pituitary cytokine network. Endocrinology. 2004 Jan; 145(1):104-12. Kariagina A, Romanenko D, Ren SG, Chesnokova V. PMID: 14512435.

View in: PubMed Mentions: 23 Fields:
End Endocrinology
Translation:Animals
Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation. Am J Physiol Endocrinol Metab. 2002 May; 282(5):E1110-8. Chesnokova V, Kariagina A, Melmed S. PMID: 11934677.

View in: PubMed Mentions: 3 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals