The Therapeutic Antibody Laboratory is interested in forming collaborative relationships, with other faculty members, on tractable and novel targets, and whose validation suggests a therapeutic approach to treat an unmet medical need. The ideal collaborator would bring clinical insight along with cell and animal models that can be used to discover and develop a family of antibody developmental candidates for licensing, partnerships, or clinical development.
Therapeutic antibodies constitute the fastest growing class of drugs today, but only a small number of potential targets have been explored thus far. Novel therapeutic concepts that propel transformative new medicines are rare, and industry has de-emphasized discovery biology. In contrast, physician-researchers lead laboratories that generate insights and predictive animal models that enlighten new drug concepts. But while universities produce many discoveries into disease related mechanisms and targets, they often lack experience in industrial drug discovery and development.
Our laboratory, as part of the Clinical and Translational Science Institute (CTSI) and David Geffen School of Medicine at UCLA, is focused on the discovery of therapeutic antibodies in collaboration with university researchers, and on understanding the drug properties that lead to clinical success.