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Precision Health Program

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Precision health has the potential to change patients’ lives. However, the ability to generalize genetic findings to diverse populations presents a major challenge. The CTSI Precision Health Program develops the infrastructure to engage diverse populations in research so as to integrate precision health discoveries and advances for clinical impact to benefit all.


Aim 1. Increase enrollment of underrepresented populations into the At Los Angeles (ATLAS) precision health biobank

  • Together with CERP, engage the Los Angeles County Department of Health Services (DHS) to increase enrollment of underrepresented populations in ATLAS.
  • With Hub partners, establish best practices for engaging individuals of limited health literacy in research.
  • With ISP and the Watts Rising Collaborative, develop and pilot an electronic pediatric assent process.

Aim 2. Develop educational materials and make recommendations for the disclosure of genetic results

  • Engage stakeholders to inform development of a framework for meaningful communication of genetic finding.
  • Develop and pilot methods to enhance provider understanding of clinically relevant genetic information.
  • Evaluate outcomes of the disclosure process to identify patient, clinician and system-level factors.

Aim 3. Disseminate tools and knowledge

  • Piloting a risk-based cancer screening program that will focus on germline variation in the BRCA family of genes across four separate diseases and piloting ROR across our Hub partners, which represent different populations, and creating methods for providers and patients to interpret these appropriately.
  • In partnership with other CTSA hubs (UC Davis, University of Colorado), establish a working group to explore adaptation of these best practices across different health systems and health conditions. These results and developed products will be shared across the CTSA consortium.