Reflecting on high-impact publications in the last year

As we look ahead to what 2023 will bring, join us in highlighting a few of the groundbreaking research developments to come out of the UCLA CTSI in 2022.

The UCLA CTSI is committed to fostering early research and mentorship for junior faculty and pre-doctoral scholars through training, funding, and professional develop opportunities. Read for more on some of the top news stories featuring CTSI TL1 Fellows and KL2 Awardees over the previous year.

• Poor sleep linked to increased risk of COPD flare-ups
  Read the press release in ScienceDaily or view the publication in Sleep.
  KL2 trainee authors: Russell Buhr (UCLA)
  
  
• US surveillance of acute ischemic stroke patient characteristics, care quality, and outcomes for 2019
  View the publication in Stroke.
  KL2 trainees: Boback Ziaeian (UCLA)
  CTSI KL2 mentor authors: Gregg C. Fonarow (UCLA)
  
  
• Bronchodilators do not improve symptomatic tobacco exposure in preserved lung function.
  Read the press release in Physicians Weekly, and more news here, or view the publication in the New England Journal of Medicine.
  KL2 trainees: Russell Buhr (UCLA)

COVID-19 research

• Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19
  View the publication in Nature.
  CTSI authors: Kara Chew (UCLA), Judith Currier (UCLA)

• Study shows inexpensive, readily available chemical may limit impact of COVID-19
  Read the press release at UCLA Health, or view the publication in Frontiers in Immunology.
  CTSI authors: Daniel Kaufman (UCLA)
  
  
• Preliminary study suggests active cannabis users had lower rates of ICU admission when hospitalized for Covid
  Read the press release in Forbes, and more news here, or view the publication in the Journal of Cannabis Research.
  CTSI authors: Russell Buhr (UCLA), Donald Tashkin (UCLA, CTSI KL2 mentor to Dr. Buhr), Nicholas Jackson (UCLA)
  
  
• Understanding the correlation between COVID-19 and flu vaccination
  Read the press release in PharmaNews Intelligence, or view the publication in the New England Journal of Medicine.
  CTSI authors: Catherine Sarkisian (UCLA)

Genetics & genomics research

• Scientists uncover nearly all genetic variants linked to height
  Read the press release at Harvard Medical School, or view the publication in Nature.
  CTSI authors: Xiuqing Guo (Lundquist/Harbor-UCLA), Jerome Rotter (Lundquist/Harbor-UCLA), Kent Taylor (Lundquist/Harbor-UCLA). Additional Lundquist authors: Marie Lauzon, Xiaohui Li, Jie Yao, Yii-Der Ida Chen.
  
  
• A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies
  View the publication in Nature Methods.
  CTSI authors: Xiuqing Guo (Lundquist/Harbor-UCLA), Jerome Rotter (Lundquist/Harbor-UCLA)
  
  
• Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function
  View the publication in Nature Genetics.
  CTSI authors: Jerome Rotter (Lundquist/Harbor-UCLA), Kent Taylor (Lundquist/Harbor-UCLA)
  
  
• Whole genome association study of the plasma metabolome identifies metabolites linked to cardiometabolic disease in black individuals
  View the publication in Nature Communications.
  CTSI authors: Xiuqing Guo (Lundquist/Harbor-UCLA), Jerome Rotter (Lundquist/Harbor-UCLA), Kent Taylor (Lundquist/Harbor-UCLA)
  
  
• Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
  View the publication in Nature Medicine.
  CTSI support: Genotyping data provisioned by eMERGE Network authors

Additional studies at CTSI partner sites

Cedars-Sinai

• Check-in phone calls boost survival in heart failure patients
  Read the press release in Newsmax Health, or view the publication in the Journal of Cardiac Failure.
  CTSI authors: Michael Ong (UCLA), James Mirocha (Cedars-Sinai)
  
  
• Geotemporal analysis of perinatal care changes and maternal mental health: an example from the COVID-19 pandemic
  View the publication in the Archives of Women’s Mental Health.
  CTSI authors:Kimberly Gregory (Cedars-Sinai), Lynne Smith (Lundquist/Harbor-UCLA)
  
  
• Body weight and physical fitness in women with ischaemic heart disease: does physical fitness contribute to our understanding of the obesity paradox in women? 
  View the publication in the European Journal of Preventative Cardiology.
  CTSI authors:Odayme Quesada (Cedars-Sinai, CTSI Cedars-Sinai Eigler-Whiting-Mann alum), Janet Wei (Cedars-Sinai, CTSI Cedars-Sinai Eigler-Whiting-Mann alum)
  
  
• Ischemic heart disease in young women JACC review topic of the week
  View the publication in the Journal of the American College of Cardiology.
  CTSI authors:Janet Wei (Cedars-Sinai)
  
  

Charles R. Drew University of Medicine and Science

• ZBED2 expression enhances interferon signaling and predicts better survival of estrogen receptor‐negative breast cancer patients
  View the publication in Cancer Communications.
  CTSI authors: Jaydutt Vadgama (Charles R. Drew University)