UCLA CTSI/CVRL is accepting applications for Team Science Award in Translational Cardiovascular Sciences from research teams at CTSI partner and affiliate institutions to conduct multidisciplinary, team-oriented and high-impact research in the area of cardiovascular diseases. Each research team will receive up to $100,000 from CTSI and an equal amount in matching funds from their home institution(s)/departments(s) spread over one or two years. The award provides salary support, benefits and research supplies.

The RFA ends: July 30th, 2012 at 5:00 p.m.

Specific Information:

Team Science Award in Translational Cardiovascular Sciences

The UCLA Clinical and Translational Science Institute in collaboration with UCLA Cardiovascular Research Laboratories is pleased to announce the UCLA CTSI Team Science Award in Translational Cardiovascular Sciences for research teams from CTSI partner institutions (UCLA, Cedars-Sinai, Charles Drew University, LA-Biomed) and CTSI-affiliated institutions (RAND, Olive View UCLA Medical Center, Santa Monica UCLA Medical Center, VA Greater Los Angeles Healthcare System) to conduct novel, multidisciplinary, team-oriented and high-impact research in the area of cardiovascular diseases. The Team Science Award in Translational Cardiovascular Sciences is intended to catalyze team science among CTSI partner and affiliate institutions to plan for submission of large extramural grants.

Cardiovascular diseases represent a major challenge in health care with limited therapeutic options. This initiative is specifically designed to meet an important goal of the UCLA CTSI: To support emerging, high-impact, multidisciplinary research programs that aim to tackle the multi-factorial complexity in the mechanisms and manifestations of the cardiovascular diseases, and to promote accelerated translation between basic science discoveries and clinical practice.

Who May Apply:

The UCLA CTSI Team Science Award in Translational Cardiovascular Sciences seeks to fund research teams of established investigators with a common focus on major cardiovascular diseases. The teams will propose projects organized around a specific area of cardiovascular research utilizing innovative, shared research approaches, tools, models and concepts to bring a new paradigm to our current understanding and to have a transformative impact in the field. The team must have matching support from home institutions(s)/department(s) committed to the program.

Specific Requirements:
1. The research team must have a minimum of three projects that revolve around a specific area of cardiovascular research and use complementary and synergistic approaches. The team-oriented approach is essential to the feasibility and potential success of the proposal.
2. Research teams must be led by a principal investigator (PI) who is full-time faculty at a CTSI partner or affiliate institution with a proven track record of high-impact research and productivity and leadership in the research area. The eligible PI should not be a principal investigator/director on an NIH Program Project (P01) at the time of award.
3. Each research project must be led by a project leader who is a full-time faculty at one of the CTSI partner or affiliate institutions and has recognized expertise to lead the proposed project.
4. PI and project leaders must be from at least two CTSI partner or affiliate institutions.
5. A strong track record of collaboration among the participating team members.
6. The proposal should not overlap with any current NIH-funded program projects in which team members participate.

Selection Criteria:
1. Impact: The proposal should have substantial impact to advance our current understanding of cardiovascular disease and to translate the new knowledge into more effective and personalized therapies.
2. Novelty: The novelty of the proposal will be evaluated at conceptual, methodological and organizational levels. It should not overlap with any existing program projects currently supported by NIH.
3. Teamwork: The proposal should foster stronger interaction among existing collaborations and create new opportunities for additional collaborations to enhance synergy.
4. Feasibility: Strong preliminary results and track record of the expertise among team members.
5. Productivity: Record of high-impact publications among team members
6. Environment: Support of home institution(s)/department(s) in matching funds.

Submission Guidelines:
1. An abstract of maximal 250 word and a 250 word limit research description in Lay language
2. One page of Specific Aims
No more than FIVE pages of Research Proposal including Significance, Innovation, Preliminary Data and Experimental Plan.
3. Program Development. One-page describing team organization, synergy and program development.
4. NIH-formatted biosketches (4-page limit with maximal of 15 representative publications) for the principal investigator, project leaders and key personnel.
5. A consolidated resource page stating major infrastructure and institutional support specifically for the proposal.

Additional Requirements:

The applicants must specify the exact extramural funding mechanism being targeted and application deadline (e.g., NHLBI P01 for June 1, 2013). Applicants must identify specific CTSI resources to be utilized and explain how the proposed research is translational.

Progress reports and end-of-project reports will be required; templates will be provided. Presentations of posters at CTSI-sponsored meetings are encouraged.

Successful applicant Co-PIs must provide their field of specialization, their NIH Commons ID and their IRB and/or IACUC numbers, if applicable, before funds are released. Recipients must credit NCATS and cite grant number UL1TR000124 in publications that result from the Team Science Award in Translational Cardiovascular Sciences.

Budgets:

Proposals must include budget and budget justification using NIH format, including personnel costs, specific planning activity costs and other support for key personnel. No indirect costs are allowed.

Award Date:

Funding will start on September 1, 2012 upon approval from CTSI

How to Apply:

Send proposal in one PDF file to UCLA-CVRL Office via email by July 30th at 5:00 p.m. to

Shaharoh Chism (Schism@mednet.ucla.edu).

All questions related to this RFA, please address to

CTSI Office of Investigator Services:

310-794-CTSI (2874) or e-mail ois@ctsi.ucla.edu

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